selected scholarly activity
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chapters
- Light Delivery and Optical Dosimetry in Photodynamic Therapy of Solid Tumors. 335-368. 2020
- Photodynamic Therapy Dosimetry: A TO Z. 295-315. 2016
- Chapter 33. Singlet Oxygen Dosimetry in Biological Media. Comprehensive Series in Photochemical and Photobiological Sciences. 151-168. 2016
- Singlet Oxygen Dosimetry in Biological Media. Comprehensive Series in Photochemical and Photobiological Sciences. 151-168. 2016
- Principles and Applications of Frequency-Domain Measurements of Light Propagation. 333-364. 1995
- OPTICAL DOSIMETRY OF PDT: IMPORTANCE OF SUPERFICIALLY APPLIED IRRADIATION BEAM SIZE. 423-423. 1991
- Applications of the Change in Tissue Optical Properties Caused by the Presence of Photosensitizers. 121-123. 1988
- The Optical Absorption and Scattering Properties of Tissues in the Visible and Near-Infrared Wavelength Range. 45-52. 1988
- The Optical Properties of Tissues at 633 Nanometers as Related to Light Dosimetry in Photodynamic Therpy. 117-119. 1988
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conferences
- Determination of in vivo photosensitizer concentrations using diffuse reflectance measurements and associative learning techniques. Proceedings of SPIE - The International Society for Optical Engineering. 226-228. 2017
- TH-C-17A-12: Integrated CBCT and Optical Tomography System On-Board a Small Animal Radiation Research Platform (SARRP). Medical Physics. 556-556. 2014
- Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector. CLEO: Applications and Technology, CLEO_AT 2013. 1-1. 2013
- WE‐A‐134‐01: Integration of X‐Ray and Optical Tomography for Precision Radiation Guidance and Real‐Time Treatment Evaluation. Medical Physics. 469-469. 2013
- WE‐C‐WAB‐05: A Novel Integrated X‐Ray and Fluorescence Tomography System for Small Animal Radiation Research Platform. Medical Physics. 478-478. 2013
- Singlet oxygen luminescence detection with a fibre-coupled superconducting nanowire single-photon detector. Optics InfoBase Conference Papers. 2013
- Reconstruction Algorithm for Fluorescence Tomography Using a Reduced Space of Eigenvectors and Optimized Source Permissible Region. Biomedical Optics and 3-D Imaging. btu3a.2. 2012
- A model-based comparison of implicit and direct dosimetry for ALA-PDT of skin. Proceedings of SPIE - The International Society for Optical Engineering. 2011
- SU‐C‐211‐05: Improved Target Localization with Integrated X‐Ray/bioluminescent Tomography. Medical Physics. 3376-3376. 2011
- SU‐E‐T‐34: Time Series Analysis of Skin Reactions during Heck and Neck IMRT. Medical Physics. 3493-3493. 2011
- TH‐C‐220‐10: Limit of Setup Accuracy Using Bioluminescence Imaging to Guide Focal Pre‐Clinical Irradiation. Medical Physics. 3864-3864. 2011
- TU-C-BRB-07: Medical Physics Staffing for Radiation Treatment: A Robust Algorithm with Trans-Canada Validation. Medical Physics. 3754-3754. 2011
- A dynamic model for ALA-PDT of skin: analysis of the correlation of fluorescence and singlet oxygen luminescence to spatial distribution of singlet oxygen. Proceedings of SPIE - The International Society for Optical Engineering. 2011
- Reconstruction algorithm for diffuse optical tomography using x-ray CT anatomical information and application to bioluminescence tomography. Proceedings of SPIE - The International Society for Optical Engineering. 2011
- PDT dosimetry: easy-as-pie or pie-in-the-sky?. 13TH INTERNATIONAL PHOTODYNAMIC ASSOCIATION WORLD CONGRESS (IPA). 63-67. 2011
- Monte carlo simulation of spatially resolved stead-state diffuse reflectance in intralumenal geometry. Optics InfoBase Conference Papers. jma104. 2010
- Patient specific integrating spheres for the improvement of dosimetry in skin PDT. Proceedings of SPIE - The International Society for Optical Engineering. 2010
- Monte Carlo Simulation Of Spatially Resolved Stead-State Diffuse Reflectance In Intralumenal Geometry. Optics InfoBase Conference Papers. 2010
- Using Pd-porphyrin phosphorescence and photodynamic oxygen consumption to study oxygen diffusion in cells. Proceedings of SPIE - The International Society for Optical Engineering. 2009
- A Monte Carlo model of detected singlet oxygen luminescence and photosensitizer fluorescence during ALA-PDT of skin. Proceedings of SPIE - The International Society for Optical Engineering. 2009
- Magnetic field effects on spectrally resolved lifetime of on-line oxygen monitoring using magneto-optic probes. Proceedings of SPIE - The International Society for Optical Engineering. 71900Y-71900Y. 2009
- Quantification of Point-Like Fluorescent Sources in Small Animals. Biomedical Optics. bwe5. 2008
- Time-resolved luminescence measurements of the magnetic field effect on paramagnetic photosensitizers in photodynamic reactions. Proceedings of SPIE - The International Society for Optical Engineering. 68450T-68450T. 2008
- Use of Magnetic Fields to Probe and Alter Photodynamic Processes in Photosensitizers. Biomedical Optics. BWB4-BWB4. 2008
- A simple approach for quantitative imaging of fluorescent point sources in small animals. Radiotherapy and Oncology. S78-S78. 2007
- Characterization and optimization of an integrating sphere-based detector for the estimation of tissue optical properties. Proceedings of SPIE - The International Society for Optical Engineering. 2007
- Post mortem evaluation of a new approach for quantitative bioluminescence imaging in small animals. Proceedings of SPIE - The International Society for Optical Engineering. 2007
- Modeling and image reconstruction in spectrally resolved bioluminescence tomography. Proceedings of SPIE - The International Society for Optical Engineering. 2007
- Characterization and optimization of an integrating sphere based detector for the estimation of tissue optical properties. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2007
- Characterization and optimization of an integrating sphere based detector for the estimation of tissue optical properties. Novel Optical Instrumentation for Biomedical Applications III. 6631_43. 2007
- Characterization of time-domain fluorescence properties of typical photosensitizers for photodynamic therapy. Proceedings of SPIE - The International Society for Optical Engineering. 64270G-64270G. 2007
- Frequency domain, time-resolved and spectroscopic investigations of photosensitizers encapsulated in liposomal phantoms. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 6632_18. 2007
- Frequency domain, time-resolved and spectroscopic investigations of photosensitizers encapsulated in liposomal phantoms. Proceedings of SPIE - The International Society for Optical Engineering. 6632_18-6632_18. 2007
- Po‐Thur Eve General‐17: Design and Characterization of a CT Scanner for Small Animal Imaging. Medical Physics. 2663-2663. 2006
- Po‐Thur Eve General‐30: Determination of the optical properties of tissue‐simulating phantoms by interstitial frequency domain measurements. Medical Physics. 2666-2666. 2006
- A Direct Linear Reconstruction Method for Spectrally Resolved 3D Bioluminescence Tomography. Optics InfoBase Conference Papers. 2006
- A direct linear reconstruction method for spectrally resolved 3D bioluminescence tomography. Optics InfoBase Conference Papers. tug5. 2006
- Determining the optical properties of tissue phantoms using an interstitial frequency domain technique. Optics InfoBase Conference Papers. 2006
- Sci‐PM Fri ‐ 02: Determination of optical properties of tissue in situ using four different frequency domain models. Medical Physics. 2421-2421. 2005
- Sci‐PM Fri ‐ 03: Potential use of diffusion theory for quantitative in vivo fluorescence and bioluminescence imaging. Medical Physics. 2421-2421. 2005
- Accuracy of a Simple Diffusion Model of Fluorescence for Estimating Fluorophore Concentration. Optics InfoBase Conference Papers. 106-113. 2003
- Accuracy of a simple diffusion theory model of fluorescence for estimating fluorophore concentration. Proceedings of SPIE - The International Society for Optical Engineering. 106-114. 2003
- <title>Measurement of singlet oxygen luminescence from AML5 cells sensitized with ALA-induced PpIX in suspension during photodynamic therapy and correlation with cell viability after treatment</title>. Proceedings of SPIE - The International Society for Optical Engineering. 93-101. 2002
- <title>Determination of <emph type="1">in vivo </emph>photosensitizer concentrations using diffuse reflectance measurements and associative learning techniques</title>. Proceedings of SPIE - The International Society for Optical Engineering. 125-134. 2002
- <title>Determination of the peak absorption wavelength and disaggregation kinetics of TOOKAD <emph type="1">in vivo </emph>using dynamic, spatially resolved diffuse reflectance spectroscopy in a rabbit model</title>. Proceedings of SPIE - The International Society for Optical Engineering. 135-142. 2002
- Detection of PDT-generated singlet oxygen in vivo by near-infrared luminescence. Lasers in Surgery and Medicine. 48-48. 2002
- Imaging Skin Cancer With Polarized Light. Optics InfoBase Conference Papers. 568-570. 2002
- Measurement of photosensitizer concentrations in tissue-simulating phantoms using fluorescence spectroscopy. Optics InfoBase Conference Papers. 714-716. 2002
- The Use of Spatially-Resolved Fluorescence to Determine Fluorophore Distributions in Layered Media. Biomedical Topical Meeting. mf3. 2002
- <title>Experimental tests of a two-layer Monte Carlo-diffusion hybrid model for photon migration in the frequency domain</title>. Proceedings of SPIE - The International Society for Optical Engineering. 313-318. 2001
- Two-layer frequency domain property measurementS-EXperi ment and hybrid model. Optics InfoBase Conference Papers. 2001
- Two-layer frequency domain property measurements - experiment and hybrid model. Technical Digest. Summaries of papers presented at the Conference on Lasers and Electro-Optics. Postconference Technical Digest (IEEE Cat. No.01CH37170). 401. 2001
- A frequency domain Monte Carlo - diffusion hybrid model for the improved determination of the optical properties of a two-layer turbid medium. Biomedical Optical Spectroscopy and Diagnostics. tud1. 2000
- A frequency domain Monte-Carlo-diffusion hybrid model for the improved determination of the optical properties of a two-layer turbid medium. Optics InfoBase Conference Papers. 360-362. 2000
- Time-resolved hemoglobin oxygenation measurements of a tissue-simulating phantom containing human erythrocytes. Optics InfoBase Conference Papers. 275-277. 2000
- <title>Estimation of the optical properties of two-layered tissue simulating phantoms from spatially resolved frequency-domain reflectance</title>. Proceedings of SPIE - The International Society for Optical Engineering. 155-163. 1999
- Experimental verification of the effect of refractive index mismatch of the light fluence in a turbid medium. Optics InfoBase Conference Papers. 195-197. 1999
- In Vivo Temperature Dependence of Human Skin Optical Properties in the NIR. Optics InfoBase Conference Papers. 250-252. 1999
- In Vivo Temperature Dependence of Human Skin Optical Properties in the NIR. Biomedical Optics. atua3. 1999
- Spatially resolved fluorescence excited by a pencil beam in layered media. Optics InfoBase Conference Papers. 343-345. 1999
- <title>Two-layered turbid media with steady-state and frequency- and time-domain reflectance</title>. Proceedings of SPIE - The International Society for Optical Engineering. 269-278. 1998
- Accuracy of the diffusion approximation in determining the optical properties of a two-layer turbid medium. Optics InfoBase Conference Papers. 11-14. 1998
- Spatially Resolved Diffuse Reflectance Measurements of Two-layered Samples in the Frequency Domain. Optics InfoBase Conference Papers. 15-19. 1998
- Spatially Resolved Diffuse Reflectance Measurements of Two-layered Samples in the Frequency Domain. Biomedical Optical Spectroscopy and Diagnostics / Therapeutic Laser Applications. bma5. 1998
- The Characterization of a Two Wavelength Time-resolved System for the Determination of Hemoglobin Saturation through Comparison with Continuous Wave and Frequency Domain Systems. Optics InfoBase Conference Papers. 192-196. 1998
- The Characterization of a Two Wavelength Time-resolved System for the Determination of Hemoglobin Saturation through Comparison with Continuous Wave and Frequency Domain Systems. Advances in Optical Imaging and Photon Migration. jwa3. 1998
- <title>Influence of tissue inhomogeneities on estimates of tissue optical properties obtained from steady-state reflectometry</title>. Proceedings of SPIE - The International Society for Optical Engineering. 335-342. 1997
- <title>Optical properties of phantoms and tissue measured in vivo from 0.9 to 1.3 um using spatially resolved diffuse reflectance</title>. Proceedings of SPIE - The International Society for Optical Engineering. 325-334. 1997
- <title>Changes in fluorescence emission during PDT due to photobleaching: potential usefulness as a marker of tissue damage</title>. Proceedings of SPIE - The International Society for Optical Engineering. 208-221. 1997
- Mechanism of ultrasound enhanced porphyrin cytotoxicity: Free radical and hematoporphrin effects. Proceedings - IEEE Ultrasonics Symposium. 1349-1352. 1997
- Noninvasive in-vivo measurements of photosensitizer uptake using diffuse reflectance spectroscopy. Proceedings of SPIE - The International Society for Optical Engineering. 136-148. 1997
- Detection of Changes in Blood Glucose Concentration in vivo with Spatially Resolved Diffuse Reflectance. Optics InfoBase Conference Papers. 2-6. 1996
- <title>Forward and inverse calculations for 3D frequency-domain diffuse optical tomography</title>. Proceedings of SPIE - The International Society for Optical Engineering. 328-339. 1995
- <title>High-performance 1D CCD camera</title>. Proceedings of SPIE - The International Society for Optical Engineering. 167-180. 1995
- <title>Investigation of multilayered tissue with in vivo reflectance measurements</title>. Proceedings of SPIE - The International Society for Optical Engineering. 212-221. 1995
- <title>General-purpose instrument for PDT dosimetry</title>. Proceedings of SPIE - The International Society for Optical Engineering. 477-481. 1994
- <title>Photodynamic therapy of normal canine prostate</title>. Proceedings of SPIE - The International Society for Optical Engineering. 427-432. 1994
- Theoretical study of the influence of sensitizer photobleaching on depth of necrosis in photodynamic therapy. Proceedings of SPIE - The International Society for Optical Engineering. 208-219. 1994
- <title>Charge-coupled device and neural-network-based instrument for the noninvasive determination of tissue optical properties in vivo</title>. Proceedings of SPIE - The International Society for Optical Engineering. 117-128. 1994
- <title>High-performance image processing system</title>. Proceedings of SPIE - The International Society for Optical Engineering. 178-188. 1994
- <title>Evaluation of prostatic optical properties and tissue response to photodynamic therapy in a canine model</title>. Proceedings of SPIE - The International Society for Optical Engineering. 416-421. 1994
- EFFECT OF FINITE VOLUMES ON NONINVASIVE FREQUENCY-DOMAIN MEASUREMENTS OF TISSUE OPTICAL-PROPERTIES. OSA PROCEEDINGS ON ADVANCES IN OPTICAL IMAGING AND PHOTON MIGRATION. 96-98. 1994
- FORWARD AND INVERSE CALCULATIONS FOR NEAR-INFRARED IMAGING USING A MULTIGRID FINITE-DIFFERENCE METHOD. OSA PROCEEDINGS ON ADVANCES IN OPTICAL IMAGING AND PHOTON MIGRATION. 176-180. 1994
- PERTURBATION CALCULATIONS OF PHOTON DENSITY WAVES INTERFERING IN AN INHOMOGENEOUS TISSUE-SIMULATING MEDIUM. OSA PROCEEDINGS ON ADVANCES IN OPTICAL IMAGING AND PHOTON MIGRATION. 74-77. 1994
- <title>Numerical modeling and experimental studies of light pulse propagation in inhomogeneous random media</title>. Proceedings of SPIE - The International Society for Optical Engineering. 90-102. 1993
- Computer simulation and experimental studies of optical imaging with photon density waves. Proceedings of SPIE - The International Society for Optical Engineering. 513-533. 1993
- <title>Instrumentation for in-vivo tissue spectroscopy and imaging</title>. Proceedings of SPIE - The International Society for Optical Engineering. 132-147. 1993
- Temperature-dependent changes in the optical absorption and scattering spectra of tissues: correlation with ultrastructure. Proceedings of SPIE - The International Society for Optical Engineering. 218-229. 1993
- <title>Photodynamic therapy in prostate cancer: optical dosimetry and response of normal tissue</title>. Proceedings of SPIE - The International Society for Optical Engineering. 231-235. 1993
- <title>Treatment parameters affecting the response of normal brain to photodynamic therapy</title>. Proceedings of SPIE - The International Society for Optical Engineering. 141-147. 1993
- INTRAVENOUS-INFUSION CHOLANGIOGRAPHY - ACCURACY IN DIAGNOSIS OF COMMON BILE-DUCT CALCULI, RELEVANCE TO LAPAROSCOPIC CHOLECYSTECTOMY, AND SAFETY. Radiology. 214-214. 1992
- <title>Acousto-optic range-Doppler processor design for radar insertion</title>. Proceedings of SPIE - The International Society for Optical Engineering. 19-30. 1992
- INVESTIGATION OF THE DEPENDENCE OF TISSUE NECROSIS ON IRRADIATION WAVELENGTH AND TIME POST INJECTION USING A PHOTODYNAMIC THRESHOLD DOSE MODEL. International Congress Series. 830-835. 1992
- THE EFFECT OF OPTICAL DOSE-RATE AND OXYGEN-SUPPLY IN PHOTODYNAMIC THERAPY OF NORMAL RAT-BRAIN. International Congress Series. 918-922. 1992
- Diffusion equation representation of photon migration in tissue. IEEE MTT-S International Microwave Symposium Digest. 905-908. 1991
- Optical ranging of muscle and brain. IEEE MTT-S International Microwave Symposium Digest. 913-916. 1991
- <title>Dependence of photodynamic threshold dose on treatment parameters in normal rat liver in vivo</title>. Proceedings of SPIE - The International Society for Optical Engineering. 146-155. 1991
- <title>In-vivo optical attenuation in normal rat brain and its implication in PDT</title>. Proceedings of SPIE - The International Society for Optical Engineering. 156-161. 1991
- <title>Time-resolved diffuse reflectance and transmittance studies in tissue simulating phantoms: a comparison between theory and experiment</title>. Proceedings of SPIE - The International Society for Optical Engineering. 42-51. 1991
- In-vivo optical attenuation in normal rat brain and its implication in PDT (Invited Paper). Proceedings of SPIE - The International Society for Optical Engineering. 156-161. 1991
- Applications of time-resolved light scattering measurements to photodynamic therapy dosimetry. Proceedings of SPIE - The International Society for Optical Engineering. 62-75. 1990
- An optical fiber-based diffuse reflectance spectrometer for non-invasive investigation of photodynamic sensitizers in vivo. Proceedings of SPIE - The International Society for Optical Engineering. 219-232. 1990
- The Potential Of Time-Resolved Reflectance Measurements For The Noninvasive Determination Of Tissue Optical Properties. Proceedings of SPIE - The International Society for Optical Engineering. 97-106. 1989
- Quantitative Reflectance Spectrophotometry For The Noninvasive Measurement Of Photosensitizer Concentration In Tissue During Photodynamic Therapy. Proceedings of SPIE - The International Society for Optical Engineering. 115-122. 1989
- Tissue Optical Properties in Relation to Light Propagation Models and in Vivo Dosimetry. PHOTON MIGRATION IN TISSUES. 25-42. 1989
- CHANGES IN TISSUE OPTICAL-PROPERTIES CAUSED BY PHOTOSENSITIZERS AND APPLICATIONS IN PHOTODYNAMIC THERAPY. Medical Physics. 455-455. 1987
- CHIRP Z-TRANSFORM FILTER. IEEE Transactions on Sonics and Ultrasonics. 98-99. 1985
- Speckle Reduction in Pulse-Echo Images by Using Phase Insensitive Summation and Multiplicative Techniques. Acoustical Imaging: Proceedings of the International Symposium. 405-412. 1985
- Improvement and Quantitative Assessment of B-mode Images Produced by Annular Array/Cone Hybrids. Acoustical Imaging: Proceedings of the International Symposium. 477-477. 1984
- COMPUTER-SIMULATIONS OF B-SCAN IMAGES. IEEE Transactions on Sonics and Ultrasonics. 186-186. 1983
- BREAST IMAGING WITH A CONICAL TRANSDUCER ANNULAR ARRAY HYBRID SCANNER. Ultrasound in Medicine and Biology. 455-455. 1982
- SIDELOBE AND SPECKLE REDUCTION FOR AN 8 SECTOR CONICAL SCANNER. IEEE Transactions on Sonics and Ultrasonics. 169-169. 1982
- Conical transducers in medical imaging. Ultrasonic Imaging. 215-215. 1981
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journal articles
- Dual-modality optical biopsy of glioblastomas multiforme with diffuse reflectance and fluorescence: ex vivo retrieval of optical properties. Journal of Biomedical Optics. 22:027002-027002. 2017
- WE-FG-BRA-06: Systematic Study of Target Localization for Bioluminescence Tomography Guided Radiation Therapy for Preclinical Research. Medical Physics. 43:3824-3824. 2016
- Systematic study of target localization for bioluminescence tomography guided radiation therapy. Medical Physics. 43:2619-2629. 2016
- Integrated Time-Resolved Fluorescence and Diffuse Reflectance Spectroscopy Instrument for Intraoperative Detection of Brain Tumor Margin. IEEE Journal of Selected Topics in Quantum Electronics. 22:49-57. 2016
- Bioluminescence Tomography–Guided Radiation Therapy for Preclinical Research. International Journal of Radiation Oncology Biology Physics. 94:1144-1153. 2016
- Experimental recovery of intrinsic fluorescence and fluorophore concentration in the presence of hemoglobin: spectral effect of scattering and absorption on fluorescence. Journal of Biomedical Optics. 20:127003-127003. 2015
- Systematic calibration of an integrated x‐ray and optical tomography system for preclinical radiation research. Medical Physics. 42:1710-1720. 2015
- 5-aminolevulinic acid induced protoporphyrin IX as a fluorescence marker for quantitative image analysis of high-grade dysplasia in Barrett’s esophagus cellular models. Journal of Biomedical Optics. 20:036010-036010. 2015
- 5-aminolevulinic acid for quantitative seek-and-treat of high-grade dysplasia in Barrett’s esophagus cellular models. Journal of Biomedical Optics. 20:028002-028002. 2015
- Correlation of in vivo tumor response and singlet oxygen luminescence detection in mTHPC-mediated photodynamic therapy. Journal of Innovative Optical Health Sciences. 08:1540006-1540006. 2015
- Time-Resolved Fluorescence in Photodynamic Therapy. Photonics. 1:530-564. 2014
- Validation and Application of a Model of Oxygen Consumption and Diffusion During Photodynamic Therapy In Vitro. Photochemistry and Photobiology. 90:1359-1367. 2014
- Measurement of Intracellular Oxygen Concentration During Photodynamic Therapy in vitro. Photochemistry and Photobiology. 90:878-888. 2014
- SU‐E‐T‐20: A Novel Hybrid CBCT, Bioluminescence and Fluorescence Tomography System for Preclinical Radiation Research. Medical Physics. 41:226-226. 2014
- Algorithm for localized adaptive diffuse optical tomography and its application in bioluminescence tomography. Physics in Medicine and Biology. 59:2089-2109. 2014
- 216: A novel dual-modality optical tomography and x-ray system for small animal radiation research platform. Radiotherapy and Oncology. 110:S105-S105. 2014
- Monitoring oxygen concentration during photodynamic therapy using prompt photosensitizer fluorescence. Physics in Medicine and Biology. 58:7039-7059. 2013
- Accuracy of Off-Line Bioluminescence Imaging to Localize Targets in Preclinical Radiation Research. Radiation Research. 179:416-421. 2013
- An integrated x-ray/optical tomography system for pre-clinical radiation research. Proceedings of SPIE - The International Society for Optical Engineering. 8668:866830. 2013
- Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector. Optics Express. 21:5005-5005. 2013
- Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector.. Optics Express. 21:5005-5013. 2013
- Effect of 1O2 quencher depletion on the efficiency of photodynamic therapy. Photochemical and Photobiological Sciences. 13:112-121. 2013
- Self-calibrated algorithms for diffuse optical tomography and bioluminescence tomography using relative transmission images. Biomedical Optics Express. 3:2794-2794. 2012
- Comparison of photodynamic therapy with different excitation wavelengths using a dynamic model of aminolevulinic acid-photodynamic therapy of human skin. Journal of Biomedical Optics. 17:0880011-0880011. 2012
- SU‐E‐T‐277: Hypothesis and Design of an Integrated X‐Ray/Bioluminescent Imaging (BLI) and Tomography (BLT) System for the Study of Radiation and Treatment in Small Animals. Medical Physics. 39:3767-3767. 2012
- 65 INTEGRATED ON-BOARD X-RAY AND BIOLUMINESCENCE TOMOGRAPHY TO GUIDE FOCAL IRRADIATION OF SOFT TISSUE TARGETS IN SMALL ANIMALS. Radiotherapy and Oncology. 102:S23-S23. 2012
- Erratum: Medical physics staffing for radiation oncology: a decade of experience in Ontario, Canada. Journal of Applied Clinical Medical Physics. 13:146-147. 2012
- Comparison of noninvasive photodynamic therapy dosimetry methods using a dynamic model of ALA-PDT of human skin. Physics in Medicine and Biology. 57:825-841. 2012
- Insights into Photodynamic Therapy Dosimetry: Simultaneous Singlet Oxygen Luminescence and Photosensitizer Photobleaching Measurements. Biophysical Journal. 102:661-671. 2012
- Medical physics staffing for radiation oncology: a decade of experience in Ontario, Canada. Journal of Applied Clinical Medical Physics. 13:93-110. 2012
- Medical physics staffing for radiation oncology: a decade of experience in Ontario, Canada. Journal of Applied Clinical Medical Physics. 13:93-110. 2012
- Monitoring Photosensitizer Uptake Using Two Photon Fluorescence Lifetime Imaging Microscopy. Theranostics. 2:817-826. 2012
- Bioluminescence tomography using eigenvectors expansion and iterative solution for the optimized permissible source region. Biomedical Optics Express. 2:3179-3179. 2011
- Calculation of Singlet Oxygen Dose Using Explicit and Implicit Dose Metrics During Benzoporphyrin Derivative Monoacid Ring A (BPD‐MA)‐PDT In Vitro and Correlation with MLL Cell Survival. Photochemistry and Photobiology. 87:1129-1137. 2011
- PDT dosimetry: Easy-as-pie or pie-in-the-sky?. Photodiagnosis and Photodynamic Therapy. 8:140-140. 2011
- Quantitative PDT dose reponses in vivo. Photodiagnosis and Photodynamic Therapy. 8:141-141. 2011
- Improved bioluminescence and fluorescence reconstruction algorithms using diffuse optical tomography, normalized data, and optimized selection of the permissible source region. Biomedical Optics Express. 2:169-169. 2011
- The Influence of Oxygen Depletion and Photosensitizer Triplet‐state Dynamics During Photodynamic Therapy on Accurate Singlet Oxygen Luminescence Monitoring and Analysis of Treatment Dose Response. Photochemistry and Photobiology. 87:223-234. 2011
- A dynamic model for ALA-PDT of skin: simulation of temporal and spatial distributions of ground-state oxygen, photosensitizer and singlet oxygen. Physics in Medicine and Biology. 55:5913-5932. 2010
- Algorithms for bioluminescence tomography incorporating anatomical information and reconstruction of tissue optical properties. Biomedical Optics Express. 1:512-512. 2010
- Integrating spheres for improved skin photodynamic therapy. Journal of Biomedical Optics. 15:058001-058001. 2010
- Fabrication and characterization of phantoms with tissue-like optical properties from 500 to 700nm. Photonics and Lasers in Medicine. 25:147-153. 2010
- Poster — Thur Eve — 38: The Effect of Ionizing Radiation on Giant Unilamellar Vesicles of “Lipid Raft” Mixtures Examined by Confocal Fluorescence Microscopy. Medical Physics. 37:3894-3894. 2010
- Calculation of Cellular Oxygen Concentration for Photodynamic Therapy In Vitro. Methods in molecular biology (Clifton, N.J.). 635:195-205. 2010
- Are higher quality papers cited more often?. Physics in Medicine and Biology. 54:i. 2009
- The relationship between reviewers’ quality-scores and number of citations for papers published in the journal Physics in Medicine and Biology from 2003–2005. Scientometrics. 80:343-349. 2009
- Simple Photodynamic Therapy Dose Models Fail to Predict the Survival of MLL Cells After HPPH–PDT In Vitro. Photochemistry and Photobiology. 85:750-759. 2009
- The use of magnetic field effects on photosensitizer luminescence as a novel probe for optical monitoring of oxygen in photodynamic therapy. Physics in Medicine and Biology. 54:1-16. 2009
- In Vitro Survival of Nonsmall Cell Lung Cancer Cells Following Combined Treatment with Ionizing Radiation and Photofrin‐mediated Photodynamic Therapy. Photochemistry and Photobiology. 85:99-106. 2009
- Quantitative fluorescence imaging of point-like sources in small animals. Physics in Medicine and Biology. 53:5797-5814. 2008
- The physics, biophysics and technology of photodynamic therapy. Physics in Medicine and Biology. 53:R61-R109. 2008
- Characterization of Fluorescence Lifetime of Photofrin and Delta-Aminolevulinic Acid Induced Protoporphyrin IX in Living Cells Using Single- and Two-Photon Excitation. IEEE Journal of Selected Topics in Quantum Electronics. 14:158-166. 2008
- Effect of liposomal confinement on photochemical properties of photosensitizers with varying hydrophilicity. Journal of Biomedical Optics. 13:041313-041313. 2008
- Effect of liposomal confinement on photothermal and photo-oximetric fluorescence lifetimes of photosensitizers with varying hydrophilicity. Journal of Biomedical Optics. 13:041314-041314. 2008
- Bioluminescence imaging of point sources implanted in small animals post mortem: evaluation of a method for estimating source strength and depth. Physics in Medicine and Biology. 52:5415-5428. 2007
- Singlet Oxygen Luminescence Dosimetry (SOLD) for Photodynamic Therapy: Current Status, Challenges and Future Prospects. Photochemistry and Photobiology. 82:1198-1210. 2006
- Quantification of bioluminescence images of point source objects using diffusion theory models. Physics in Medicine and Biology. 51:3733-3746. 2006
- Application of the modified spherical harmonics method to some problems in biomedical optics. Physics in Medicine and Biology. 51:N247-N251. 2006
- Determination of the optical properties of tissue-simulating phantoms from interstitial frequency domain measurements of relative fluence and phase difference. Optics Express. 14:6485-6485. 2006
- Investigation of light propagation models to determine the optical properties of tissue from interstitial frequency domain fluence measurements. Journal of Biomedical Optics. 11:041104-041104. 2006
- Photobleaching kinetics, photoproduct formation, and dose estimation during ALA induced PpIX PDT of MLL cells under well oxygenated and hypoxic conditions. Photochemical and Photobiological Sciences. 5:73-81. 2006
- Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry. Journal of Biomedical Optics. 11:041102-041102. 2006
- Spectrally resolved bioluminescence optical tomography. Optics Letters. 31:365-365. 2006
- Imaging of Photodynamically Generated Singlet Oxygen Luminescence In Vivo¶. Photochemistry and Photobiology. 81:941-943. 2005
- Po‐Poster ‐ 33: A finite element model for bioluminescence imaging in small animals. Medical Physics. 32:2416-2416. 2005
- Sci‐YIS Fri ‐ 03: Calculation of singlet oxygen dose from photosensitizer photobleaching during mTHPC or Photofrin photodynamic therapy in vitro. Medical Physics. 32:2419-2419. 2005
- Characterization of Photofrin photobleaching for singlet oxygen dose estimation during photodynamic therapy of MLL cellsin vitro. Physics in Medicine and Biology. 50:2597-2616. 2005
- Calculation of Singlet Oxygen Dose from Photosensitizer Fluorescence and Photobleaching During mTHPC Photodynamic Therapy of MLL Cells¶. Photochemistry and Photobiology. 81:196-205. 2005
- Quantification of fluorophore concentration in vivo using two simple fluorescence-based measurement techniques. Journal of Biomedical Optics. 10:024007-024007. 2005
- Singlet oxygen luminescence as an in vivo photodynamic therapy dose metric: validation in normal mouse skin with topical amino-levulinic acid. British Journal of Cancer. 92:298-304. 2005
- Photobleaching kinetics of Photofrinin vivoand in multicell tumour spheroids indicate two simultaneous bleaching mechanisms. Physics in Medicine and Biology. 49:4837-4860. 2004
- Medical Physicstop ten. Medical Physics. 31:682-682. 2004
- Physics in Medicine and Biology top ten. Physics in Medicine and Biology. 49:L1-L4. 2004
- Measurement of fluorophore concentrations and fluorescence quantum yield in tissue-simulating phantoms using three diffusion models of steady-state spatially resolved fluorescence. Physics in Medicine and Biology. 48:4135-4149. 2003
- In vitro tests of the validity of singlet oxygen luminescence measurements as a dose metric in photodynamic therapy.. Cancer Research. 63:7986-7994. 2003
- The use of spatially resolved fluorescence and reflectance to determine interface depth in layered fluorophore distributions. Physics in Medicine and Biology. 48:3459-3474. 2003
- Quantification of fluorophore concentration in tissue-simulating media by fluorescence measurements with a single optical fiber. Applied Optics. 42:2436-2436. 2003
- Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron. Kidney International. 63:1321-1337. 2003
- Direct Near-infrared Luminescence Detection of Singlet Oxygen Generated by Photodynamic Therapy in Cells In Vitro and Tissues In Vivo¶. Photochemistry and Photobiology. 75:382-391. 2002
- Haemoglobin oxygenation of a two-layer tissue-simulating phantom from time-resolved reflectance: effect of top layer thickness. Physics in Medicine and Biology. 47:193-208. 2002
- Relationship Between mTHPC Fluorescence Photobleaching and Cell Viability During In Vitro Photodynamic Treatment of DP16 Cells¶. Photochemistry and Photobiology. 75:289-289. 2002
- Noninvasive measurement of fluorophore concentration in turbid media with a simple fluorescence/reflectance ratio technique. Applied Optics. 40:6389-6389. 2001
- Determination of the optical properties of two-layer turbid media by use of a frequency-domain hybrid Monte Carlo diffusion model. Applied Optics. 40:3810-3810. 2001
- A diffusion theory model of spatially resolved fluorescence from depth-dependent fluorophore concentrations. Physics in Medicine and Biology. 46:369-383. 2001
- Experimental verification of the effect of refractive index mismatch on the light fluence in a turbid medium. Journal of Biomedical Optics. 6:468-468. 2001
- Anisotropy of light propagation in human skin. Physics in Medicine and Biology. 45:2873-2886. 2000
- Monte Carlo diffusion hybrid model for photon migration in a two-layer turbid medium in the frequency domain. Applied Optics. 39:2235-2235. 2000
- Accuracy of the diffusion approximation in determining the optical properties of a two-layer turbid medium. Applied Optics. 37:7401-7401. 1998
- Modeling of photosensitizer fluorescence emission and photobleaching for photodynamic therapy dosimetry. Applied Optics. 37:7168-7168. 1998
- Comparison of the In Vivo Photodynamic Threshold Dose for Photofrin, Mono‐ and Tetrasulfonated Aluminum Phthalocyanine Using a Rat Liver Model. Photochemistry and Photobiology. 68:394-399. 1998
- Influence of layered tissue architecture on estimates of tissue optical properties obtained from spatially resolved diffuse reflectometry. Applied Optics. 37:1958-1958. 1998
- Improved continuous light diffusion imaging in single- and multi-target tissue-like phantoms. Physics in Medicine and Biology. 43:675-693. 1998
- Frequency‐domain near‐infrared photo diffusion imaging: Initial evaluation in multitarget tissuelike phantoms. Medical Physics. 25:183-193. 1998
- Noninvasive determination of the optical properties of two-layered turbid media. Applied Optics. 37:779-779. 1998
- Comparison of the In Vivo Photodynamic Threshold Dose for Photofrin, Mono- and Tetrasulfonated Aluminum Phthalocyanine Using a Rat Liver Model. Photochemistry and Photobiology. 68:394-394. 1998
- Absorbed photodynamic dose from pulsed versus continuous wave light examined with tissue-simulating dosimeters. Applied Optics. 36:7257-7257. 1997
- Implicit and explicit dosimetry in photodynamic therapy: a New paradigm. Lasers in Medical Science. 12:182-199. 1997
- Accuracy of Noninvasive in vivo Measurements of Photosensitizer Uptake Based on a Diffusion Model of Reflectance Spectroscopy. Photochemistry and Photobiology. 66:326-335. 1997
- Determination of the optical properties of semi-infinite turbid media from frequency-domain reflectance close to the source. Physics in Medicine and Biology. 42:1801-1819. 1997
- Frequency-domain optical image reconstruction in turbid media: an experimental study of single-target detectability: erratum. Applied Optics. 36:2995-2995. 1997
- Imaging of fluorescent yield and lifetime from multiply scattered light reemitted from random media. Applied Optics. 36:2260-2260. 1997
- Correlation between blood glucose concentration in diabetics and noninvasively measured tissue optical scattering coefficient. Optics Letters. 22:190-190. 1997
- Changes in In Vivo Optical Properties and Light Distributions in Normal Canine Prostate during Photodynamic Therapy. Radiation Research. 147:86-86. 1997
- Frequency-domain optical image reconstruction in turbid media: an experimental study of single-target detectability. Applied Optics. 36:52-52. 1997
- Improved solutions of the steady-state and the time-resolved diffusion equations for reflectance from a semi-infinite turbid medium. Journal of the Optical Society of America A: Optics and Image Science, and Vision. 14:246-246. 1997
- Erratum: The sensitivity of normal brain and intracranially implanted VX2 tumour to interstitial photodynamic therapy. British Journal of Cancer. 74:1691-1691. 1996
- Determination of the optical properties of turbid media from a single Monte Carlo simulation. Physics in Medicine and Biology. 41:2221-2227. 1996
- Determination of the scattering coefficient and the anisotropy factor from laser Doppler spectra of liquids including blood. Applied Optics. 35:3404-3404. 1996
- Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue. Applied Optics. 35:2304-2304. 1996
- Why do veins appear blue? A new look at an old question. Applied Optics. 35:1151-1151. 1996
- Optical image reconstruction using frequency-domain data: simulations and experiments. Journal of the Optical Society of America A: Optics and Image Science, and Vision. 13:253-253. 1996
- The sensitivity of normal brain and intracranially implanted VX2 tumour to interstitial photodynamic therapy. British Journal of Cancer. 73:332-343. 1996
- Error assessment of a wavelength tunable frequency domain system for noninvasive tissue spectroscopy. Journal of Biomedical Optics. 1:311-311. 1996
- Simultaneous reconstruction of optical absorption and scattering maps in turbid media from near-infrared frequency-domain data. Optics Letters. 20:2128-2128. 1995
- Initial assessment of a simple system for frequency domain diffuse optical tomography. Physics in Medicine and Biology. 40:1709-1729. 1995
- Absorption spectroscopy in tissue-simulating materials: a theoretical and experimental study of photon paths. Applied Optics. 34:22-22. 1995
- Frequency-domain optical absorption spectroscopy of finite tissue volumes using diffusion theory. Physics in Medicine and Biology. 39:1157-1180. 1994
- Mathematical model for time-resolved and frequency-domain fluorescence spectroscopy in biological tissues. Applied Optics. 33:1963-1963. 1994
- The use of a neural network to determine tissue optical properties from spatially resolved diffuse reflectance measurements. Physics in Medicine and Biology. 37:2281-2286. 1992
- The Effect of Light Fluence Rate in Photodynamic Therapy of Normal Rat Brain. Radiation Research. 132:120-120. 1992
- EFFECTS OF LIGHT BEAM SIZE ON FLUENCE DISTRIBUTION AND DEPTH OF NECROSIS IN SUPERFICIALLY APPLIED PHOTODYNAMIC THERAPY OF NORMAL RAT BRAIN. Photochemistry and Photobiology. 56:379-384. 1992
- A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo. Medical Physics. 19:879-888. 1992
- Experimental tests of a simple diffusion model for the estimation of scattering and absorption coefficients of turbid media from time-resolved diffuse reflectance measurements. Applied Optics. 31:3509-3509. 1992
- Time-dependent optical spectroscopy and imaging for biomedical applications. Proceedings of the IEEE. 80:918-930. 1992
- The use of India ink as an optical absorber in tissue-simulating phantoms. Physics in Medicine and Biology. 37:985-993. 1992
- The propagation of optical radiation in tissue. II: Optical properties of tissues and resulting fluence distributions. Lasers in Medical Science. 6:379-390. 1991
- Frequency-domain reflectance for the determination of the scattering and absorption properties of tissue. Applied Optics. 30:4474-4474. 1991
- The propagation of optical radiation in tissue I. Models of radiation transport and their application. Lasers in Medical Science. 6:155-168. 1991
- Optical properties of normal and diseased human breast tissues in the visible and near infrared. Physics in Medicine and Biology. 35:1317-1334. 1990
- Experimental tests of the feasibility of singlet oxygen luminescence monitoring in vivo during photodynamic therapy. Journal of Photochemistry and Photobiology B: Biology. 5:69-84. 1990
- In vivo TESTS OF THE CONCEPT OF PHOTODYNAMIC THRESHOLD DOSE IN NORMAL RAT LIVER PHOTOSENSITIZED BY ALUMINUM CHLOROSULPHONATED PHTHALOCYANINE. Photochemistry and Photobiology. 51:343-349. 1990
- In vivo optical properties of normal rat brain and application in photodynamic therapy. International Journal of Radiation Oncology Biology Physics. 19:259-259. 1990
- Similarity relations for the interaction parameters in radiation transport. Applied Optics. 28:5243-5243. 1989
- Monte Carlo modeling of light propagation in highly scattering tissues--II: Comparison with measurements in phantoms.. IEEE Transactions on Biomedical Engineering. 36:1169-1173. 1989
- Monte Carlo modeling of light propagation in highly scattering tissues. I. Model predictions and comparison with diffusion theory. IEEE Transactions on Biomedical Engineering. 36:1162-1168. 1989
- Time resolved reflectance and transmittance for the noninvasive measurement of tissue optical properties. Applied Optics. 28:2331-2331. 1989
- Similarity relations for anisotropic scattering in Monte Carlo simulations of deeply penetrating neutral particles. Journal of Computational Physics. 81:137-150. 1989
- Hybrid Monte Carlo - Diffusion Theory Modelling Of Light Distributions In Tissue.. Proceedings of SPIE - The International Society for Optical Engineering. 908:20-28. 1988
- A discrete method for anisotropic angular sampling in Monte Carlo simulations. Journal of Computational Physics. 76:414-425. 1988
- INDIRECT VERSUS DIRECT TECHNIQUES FOR THE MEASUREMENT OF THE OPTICAL PROPERTIES OF TISSUES. Photochemistry and Photobiology. 46:601-608. 1987
- THE MEASUREMENT OF DIHEMATOPORPHYRIN ETHER CONCENTRATION IN TISSUE BY REFLECTANCE SPECTROPHOTOMETRY. Photochemistry and Photobiology. 46:337-343. 1987
- Total attenuation coefficients and scattering phase functions of tissues and phantom materials at 633 nm. Medical Physics. 14:835-841. 1987
- Effect of photosensitizer concentration in tissue on the penetration depth of photoactivating light. Lasers in Medical Science. 1:235-244. 1986
- The physics of photodynamic therapy. Physics in Medicine and Biology. 31:327-360. 1986
- Quantitative contrast measurements in B-mode images comparison between experiment and theory. Ultrasound in Medicine and Biology. 12:197-208. 1986
- Speckle Reduction in Pulse Echo Imaging Using Phase Insensitive and Phase Sensitive Signal Processing Techniques. Ultrasonic Imaging. 8:11-28. 1986
- Speckle reduction in pulse echo imaging using phase insensitive and phase sensitive signal processing techniques. Ultrasonic Imaging. 8:11-28. 1986
- Artifactual echoes in B-mode images due to multiple scattering. Ultrasound in Medicine and Biology. 11:99-111. 1985
- Computer Simulations of Speckle in B-Scan Images. Ultrasonic Imaging. 5:308-330. 1983
- The improvement and quantitative assessment of B-mode images produced by an annular array/cone hybrid.. Ultrasonic Imaging. 5:195-213. 1983
- Breast imaging with a conical transducer/ annular array hybrid scanner. Ultrasound in Medicine and Biology. 9:151-164. 1983
- Acoustic Fields of Conical Radiators. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 29:83-91. 1982
- Improved method for the design of tissue compensators. Medical Physics. 8:885-891. 1981
- Characteristics of an 18 MV photon beam from a Therac 20 Medical Linear Accelerator. Medical Physics. 8:312-318. 1981
- Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. IX. The quantitation of natural killer cell activity. Journal of Clinical Immunology. 1:51-63. 1981
- The conical scanner: a two transducer ultrasound scatter imaging technique.. Ultrasonic Imaging. 3:62-82. 1981
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preprints