Journal article
Effect of nicotine on quinpirole-induced checking behavior in rats: implications for obsessive-compulsive disorder
Abstract
BACKGROUND: Rats treated chronically in a large, open field with the dopamine D2/D3 receptor agonist quinpirole (QNP) develop compulsive checking behavior as defined by a set of behavioral criteria. This paradigm has been suggested as an animal model of obsessive-compulsive disorder (OCD). Because nicotine blocks various behaviors induced by ontogenetic QNP administration, we asked whether nicotine could attenuate QNP-induced compulsive …
Authors
Tizabi Y; Louis VA; Taylor CT; Waxman D; Culver KE; Szechtman H
Journal
Biological Psychiatry, Vol. 51, No. 2, pp. 164–171
Publisher
Elsevier
Publication Date
January 2002
DOI
10.1016/s0006-3223(01)01207-0
ISSN
0006-3223