Journal article
Nuclear Kaiso Expression Is Associated with High Grade and Triple-Negative Invasive Breast Cancer
Abstract
Kaiso is a BTB/POZ transcription factor that is ubiquitously expressed in multiple cell types and functions as a transcriptional repressor and activator. Little is known about Kaiso expression and localization in breast cancer. Here, we have related pathological features and molecular subtypes to Kaiso expression in 477 cases of human invasive breast cancer. Nuclear Kaiso was predominantly found in invasive ductal carcinoma (IDC) (p = 0.007), …
Authors
Vermeulen JF; van de Ven RAH; Ercan C; van der Groep P; van der Wall E; Bult P; Christgen M; Lehmann U; Daniel J; van Diest PJ
Journal
PLOS ONE, Vol. 7, No. 5,
Publisher
Public Library of Science (PLoS)
Publication Date
2012
DOI
10.1371/journal.pone.0037864
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adherens JunctionsAdultAgedAged, 80 and overAnimalsBreast NeoplasmsCadherinsCarcinoma, LobularCell LineCell NucleusErbB ReceptorsFemaleGene ExpressionHumansMiceMiddle AgedNeoplasm GradingNeoplasm InvasivenessProtein TransportReceptor, ErbB-2Receptors, EstrogenReceptors, ProgesteroneTranscription Factorsp120 GTPase Activating Protein