Kindling, Neurotrophins and Axon-Guidance Factors

Graham Goddard1 initially introduced kindling as a model for memory. Although most frequently utilized as an epilepsy model, particularly for temporal lobe epilepsy, kindling is occasionally used as a model for drug-induced plasticity, slowly developing neuropathologies other than epilepsy, and a variety of structural reorganizations of brain circuitry.2,3 Since our interest in the kindling phenomenon (and other models of epilepsy) is largely …