Journal article
A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes
Abstract
Herpes simplex virus (HSV) infection of human fibroblasts rapidly renders the cells resistant to lysis by HSV-specific CD8+ cytotoxic T lymphocytes (CTLs), which normally recognize cell surface major histocompatibility complex (MHC) class I proteins presenting viral peptides. Within 3 hr of infection with HSV, MHC class I protein complexes are retained in the endoplasmic reticulum (ER)/cis Golgi and show properties of complexes lacking …
Authors
York IA; Roop C; Andrews DW; Riddell SR; Graham FL; Johnson DC
Journal
Cell, Vol. 77, No. 4, pp. 525–535
Publisher
Elsevier
Publication Date
5 1994
DOI
10.1016/0092-8674(94)90215-1
ISSN
0092-8674
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid SequenceAnimalsAntigen PresentationCD8 AntigensCell LineCell NucleusCytoplasmCytotoxicity, ImmunologicEndoplasmic ReticulumFibroblastsGene ExpressionHistocompatibility Antigens Class IHumansImmediate-Early ProteinsMolecular Sequence DataMutationProtein FoldingRecombinant ProteinsSimplexvirusT-Lymphocytes, Cytotoxicbeta 2-Microglobulin