Heterosynaptic interactions between septal and entorhinal inputs to the dentate gyrus: long-term potentiation effects

Cooperative interactions between neural pathways, in the production of long-term potentiation, may serve as models of associative memory. Brief, high-frequency activation of the septodentate input to dentate gyrus granule cells was found to produce only a short-term heterosynaptic potentiation of the perforant path-granule cell (PP-GC) population spike. Concurrent tetanization of perforant path and septodentate afferents, however, resulted in significantly greater long-term potentiation of the PP-GC population spike than was produced by tetanization of the perforant path alone.