Journal article
Investigation of blood-brain barrier disruption in an animal model of mania induced by D-amphetamine
Abstract
Background High levels of inflammation and oxidative stress are observed in bipolar disorder (BD) being further associated with mood symptoms and cognitive dysfunction. Due to the crosstalk between the periphery and central nervous system, the blood-brain barrier (BBB) disruption has been considered a key mechanism of the BD pathophysiology. This study aimed to evaluate claudin-5 expression in the brain of a model of mania induced by …
Authors
Géa LP; Wollenhaupt-Aguiar B; Watts D; Maich W; Kapczinski F; Sharma R; Mishra R; Rosa AR; Frey BN
Journal
Journal of Affective Disorders Reports, Vol. 9, ,
Publisher
Elsevier
Publication Date
July 2022
DOI
10.1016/j.jadr.2022.100368
ISSN
2666-9153