Journal article
Intragraft CD11b+IDO+ Cells Mediate Cardiac Allograft Tolerance by ECDI-Fixed Donor Splenocyte Infusions
Abstract
We have previously shown that pre- and post-transplant infusions of donor splenocytes treated with 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide (ECDI-SPs) provide permanent donor-specific protection of islet allografts. The efficacy of donor ECDI-SPs in protecting vascularized cardiac allografts and mechanism(s) of protection are unknown. In this study, we show that infusions of ECDI-SPs significantly prolong cardiac allograft survival …
Authors
Chen G; Kheradmand T; Bryant J; Wang S; Tasch J; Wang J-J; Zhang Z; Luo X
Journal
American Journal of Transplantation, Vol. 12, No. 11, pp. 2920–2929
Publisher
Elsevier
Publication Date
November 2012
DOI
10.1111/j.1600-6143.2012.04203.x
ISSN
1600-6135
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Analysis of VarianceAnimalsAntigen-Presenting CellsCD11b AntigenCell TransplantationDisease Models, AnimalFluorescent Antibody TechniqueGraft RejectionGraft SurvivalHeart TransplantationImmunohistochemistryIndoleamine-Pyrrole 2,3,-DioxygenaseIsoantigensMaleMiceMice, Inbred BALB CRandom AllocationSirolimusSpleenStatistics, NonparametricTransplantation ToleranceTransplantation, Homologous