Journal article
An Automated Multidose Synthesis of the Potentiometric PET Probe 4-[18F]Fluorobenzyl-Triphenylphosphonium ([18F]FBnTP)
Abstract
PurposeThe aim of this study was the automated synthesis of the mitochondrial membrane potential sensor 4-[18F]fluorobenzyl-triphenylphosphonium ([18F]FBnTP) on a commercially available synthesizer in activity yields (AY) that allow for imaging of multiple patients.ProceduresA three-pot, four-step synthesis was implemented on the ELIXYS FLEX/CHEM radiosynthesizer (Sofie Biosciences) and optimized for radiochemical yield (RCY), radiochemical …
Authors
Waldmann CM; Gomez A; Marchis P; Bailey ST; Momcilovic M; Jones AE; Shackelford DB; Sadeghi S
Journal
Molecular Imaging and Biology, Vol. 20, No. 2, pp. 205–212
Publisher
Springer Nature
Publication Date
April 2018
DOI
10.1007/s11307-017-1119-1
ISSN
1536-1632