Chronic cardiac output measurement in unrestrained rats: surgical description
Abstract
The poster contains work done on rat-animal model where midline thoracotomy vs. lateral intercostal thoracotomy were used to install transit time cardiac flow probe. Comparing these 2 surgical techniques, midline thoracotomy was considered superior as for an earlier data capture, superior flow probe placement on the ascending aorta/aortic root and faster animal recovery without data dropouts or signal/noise interference. Survival at day 6 seems to be similar at this time, however more animals are needed to confirm it. Post-application of isoproterenol (8ug/kg s.c.), CO and HR has transiently increased showing ability to detect change of CO after animal has recovered post-day 3.
Authors
Konecny F; Newton-Northup J; Callahan M; Pitsillides K; Sosa M