Journal article
Fixed-dose combination therapies with and without aspirin for primary prevention of cardiovascular disease: an individual participant data meta-analysis
Abstract
BACKGROUND: In randomised controlled trials, fixed-dose combination treatments (or polypills) have been shown to reduce a composite of cardiovascular disease outcomes in primary prevention. However, whether or not aspirin should be included, effects on specific outcomes, and effects in key subgroups are unknown.
METHODS: We did an individual participant data meta-analysis of large randomised controlled trials (each with ≥1000 participants and …
Authors
Joseph P; Roshandel G; Gao P; Pais P; Lonn E; Xavier D; Avezum A; Zhu J; Liu L; Sliwa K
Journal
The Lancet, Vol. 398, No. 10306, pp. 1133–1146
Publisher
Elsevier
Publication Date
September 2021
DOI
10.1016/s0140-6736(21)01827-4
ISSN
0140-6736