Journal article
Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock
Abstract
BACKGROUND: Vasopressin is commonly used as an adjunct to catecholamines to support blood pressure in refractory septic shock, but its effect on mortality is unknown. We hypothesized that low-dose vasopressin as compared with norepinephrine would decrease mortality among patients with septic shock who were being treated with conventional (catecholamine) vasopressors.
METHODS: In this multicenter, randomized, double-blind trial, we assigned …
Authors
Russell JA; Walley KR; Singer J; Gordon AC; Hébert PC; Cooper DJ; Holmes CL; Mehta S; Granton JT; Storms MM
Journal
New England Journal of Medicine, Vol. 358, No. 9, pp. 877–887
Publisher
Massachusetts Medical Society
Publication Date
February 28, 2008
DOI
10.1056/nejmoa067373
ISSN
0028-4793