Journal article
Adenoviral-transduced dendritic cells are susceptible to suppression by T regulatory cells and promote interleukin 17 production
Abstract
Dendritic cell (DC) vaccines offer a robust platform for the development of cancer vaccines, but their effectiveness is thought to be limited by T regulatory cells (Tregs). Recombinant adenoviruses (RAdV) have been used successfully to engineer tumor antigen expression in DCs, but the impact of virus transduction on susceptibility to suppression by Tregs is unknown. We investigated the functional consequences of exposure to adenovirus on …
Authors
Wang AY; Crome SQ; Jenkins KM; Medin JA; Bramson JL; Levings MK
Journal
Cancer Immunology, Immunotherapy, Vol. 60, No. 3, pp. 381–388
Publisher
Springer Nature
Publication Date
March 2011
DOI
10.1007/s00262-010-0948-4
ISSN
0340-7004