Abnormal Melanosomes: Ultrastructural Markers of Melanocytic Atypia Journal Articles uri icon

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  • To identify possible ultrastructural markers of melanocytic atypia, a quantitative ultrastructural study was made of melanocytes found at the dermal-epidermal boundary of normal skin and in benign, premalignant, and malignant melanocytic lesions. There was a significant increase (p < 0.05) in the number of melanosomes per melanocyte in the premalignant and malignant lesions compared with the number observed in the benign lesions. There was a significantly higher number (p < 0.05) of abnormal melanosomes (with irregularities in the laminar matrix or with a granular or clumpy matrix) in the premalignant and malignant lesions, which suggests that the presence of a high percentage of abnormal melanosomes might act as a useful ultrastructural marker in the diagnosis of melanocytic atypia.


  • Ortega, V Vicente
  • Díaz, F Martínez
  • Romero, C Carrascosa
  • Pacheco, G Ortuño
  • Jordana, Manel
  • Rubiales, F Calderón

publication date

  • January 1995