Journal article
Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema
Abstract
OBJECTIVE: The objective of this study was to identify genetic variants associated with angiotensin-converting enzyme (ACE) inhibitor-associated angioedema.
PARTICIPANTS AND METHODS: We carried out a genome-wide association study in 175 individuals with ACE inhibitor-associated angioedema and 489 ACE inhibitor-exposed controls from Nashville (Tennessee) and Marshfield (Wisconsin). We tested for replication in 19 cases and 57 controls who …
Authors
Pare G; Kubo M; Byrd JB; McCarty CA; Woodard-Grice A; Teo KK; Anand SS; Zuvich RL; Bradford Y; Ross S
Journal
Pharmacogenetics and Genomics, Vol. 23, No. 9, pp. 470–478
Publisher
Wolters Kluwer
Publication Date
September 2013
DOI
10.1097/fpc.0b013e328363c137
ISSN
1744-6872
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Black or African AmericanAngioedemaAngiotensin-Converting Enzyme InhibitorsBenzimidazolesBenzoatesDouble-Blind MethodDrug Therapy, CombinationGenome-Wide Association StudyHumansIsoenzymesNeprilysinPolymorphism, Single NucleotideProtein Kinase CProtein Kinase C-thetaProto-Oncogene Proteins c-etsRamiprilRepressor ProteinsTelmisartanWhite PeopleETS Translocation Variant 6 Protein