Journal article
A Versatile Platform for the Development of Radiolabeled Antibody-Recruiting Small Molecules
Abstract
Building on clinical case reports of the abscopal effect, there has been considerable interest in the synergistic effects of radiation and immunotherapies for the treatment of cancer. Here, the first radiolabeled antibody-recruiting small molecule that can chelate a variety of cytotoxic radionuclides is described. The platform consists of a tunable antibody-binding domain against a serum antibody of interest (e.g., dinitrophenyl hapten) to …
Authors
Rathmann SM; Genady AR; Janzen N; Anipindi V; Czorny S; Rullo AF; Sadeghi S; Valliant JF
Journal
Molecular Pharmaceutics, Vol. 18, No. 7, pp. 2647–2656
Publisher
American Chemical Society (ACS)
Publication Date
July 5, 2021
DOI
10.1021/acs.molpharmaceut.1c00187
ISSN
1543-8384