A301 GUT MICROBIOTA FROM A PATIENT WITH GENERALIZED ANXIETY DISORDER INDUCES ANXIETY-LIKE BEHAVIOUR AND ALTERED BRAIN CHEMISTRY IN GNOTOBIOTIC MICE

Depression and anxiety have overlapping etiologies and their pathophysiology remains largely unknown. Accumulating data suggest that gut microbiota modulates brain function and behaviour and may play a role in the pathophysiology of depression and anxiety To investigate whether gut microbiota from patients with Generalized Anxiety Disorder (GAD) induces anxiety-like behaviour in gnotobiotic mice and whether this is accompanied by changes in …