DetailedAnalysis of the CD8 + T-Cell Response followingAdenovirusVaccination Journal Articles uri icon

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abstract

  • ABSTRACT We examined CD8 + T-cell expansion and function following intramuscular immunization with a recombinant adenovirus. This study has identified a number of properties which may explain the strong immunogenicity of adenovirus vectors: (i) the ability to deliver large amounts of antigen into the lymphoid tissues, (ii) the ability to induce rapid expansion and migration of CD8 + T cells throughout the lymphatics, and (iii) the ability to produce a sustained, high-level CD8 + T-cell response.

publication date

  • December 15, 2003