Journal article
Novel mechanism of action for the mood stabilizer lithium
Abstract
BACKGROUND: Bipolar Disorder (BD) is associated with a decrease in cellular resilience. Despite the half a century old discovery of lithium's efficacy for the treatment of BD, its exact mechanisms remain elusive. Accumulating data suggest that lithium's cytoprotective properties involve the modulation of several UPR proteins, such as GRP78. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum resident protein …
Authors
Abu‐Hijleh FA; Prashar S; Joshi H; Sharma R; Frey BN; Mishra RK
Journal
Bipolar Disorders, Vol. 23, No. 1, pp. 76–83
Publisher
Wiley
Publication Date
February 2021
DOI
10.1111/bdi.13019
ISSN
1398-5647