Prostaglandins prevent acetaminophen induced embryo toxicity in zebrafish (Danio rerio)

Previous research in our laboratory showed that acetaminophen (ACE) induced embryonic mortality and abnormalities in zebrafish. Here, we examined the dose response of ACE (0.05-50 μg L^-1) in zebrafish embryos. Concentrations as low as 0.1 μg L^-1 significantly increased abnormalities, and all test concentrations significantly increased mortality rates. In mammals, ACE inhibits cyclooxygenase (COX) enzymes to decrease prostaglandin production. …