Methodological assessment of Mexican Clinical Practice Guidelines: GRADE framework adherence and critical appraisal Academic Article uri icon

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  • BACKGROUND AND OBJECTIVE: Clinical Practice Guidelines (CPGs) provide evidence-based recommendations to healthcare professionals, policy makers, patients and other stakeholders. Mexico is the biggest producer of CPGs in Latin America and Caribbean countries. The National Healthcare Technology Excellence Center (acronym in Spanish: CENETEC) is responsible for the CPG development, adaptation and update. The aim of this study was to assess the adherence to the GRADE framework and to critically appraise the Mexican CPGs with the AGREE-II tool. STUDY DESIGN: We conducted a descriptive cross-sectional study with a random sample of 86 CPGs produced by CENETEC between 2015 and 2017 and published in an online database called "Catalogo Maestro". We assessed the adherence to the GRADE framework and performed a critical appraisal with the AGREE II tool. RESULTS: Of the 86 CPGs, 34 were published in 2015, 21 in 2016 and 31 in 2017. Of the 86 CPGs, 25 (29%) used the GRADE framework; adherence to GRADE standards was, however, inconsistent and generally poor. The overall methodological quality by AGREE II proved a median of 16.6% (Min 16.6%, Max 50%). CONCLUSION: CPGs produced by CENETEC during this period had a poor adherence to the GRADE framework and low score by AGREE II standards. A concerted initiative could rapidly improve CENETEC guidelines.


  • Colunga‐Lozano, Luis Enrique
  • Gerardo‐Morales, Vilma
  • Pérez‐Gaxiola, Giordano
  • Vázquez‐Álvarez, Alan Omar
  • González‐Torres, Francisco Javier
  • Perales‐Guerrero, Leonardo
  • Yanowsky‐Ortega, Ekatherina
  • Martínez‐Tolentino, Ulises Ivan
  • Sánchez‐Villaseca, Sergio Jacob
  • García‐Macías, Luz Angélica
  • Nieuwlaat, Robby
  • Guyatt, Gordon
  • Florez, Ivan

publication date

  • April 2021