Journal article
Multiple daily doses of acetyl‐salicylic acid (ASA) overcome reduced platelet response to once‐daily ASA after coronary artery bypass graft surgery: a pilot randomized controlled trial
Abstract
BACKGROUND: The efficacy of ASA for prevention of graft failure following CABG surgery may be limited by incomplete platelet inhibition due to increased post-operative platelet turnover.
OBJECTIVES: To determine whether acetyl-salicylic acid (ASA) 325 mg once-daily or 81 mg four-times daily overcomes the impaired response to ASA 81 mg once-daily in post-operative coronary artery bypass graft (CABG) patients.
Authors
Paikin JS; Hirsh J; Ginsberg JS; Weitz JI; Chan NC; Whitlock RP; Pare G; Johnston M; Eikelboom JW
Journal
Journal of Thrombosis and Haemostasis, Vol. 13, No. 3, pp. 448–456
Publisher
Elsevier
Publication Date
March 2015
DOI
10.1111/jth.12832
ISSN
1538-7933