Journal article
Common Low-Density Lipoprotein Receptor p.G116S Variant Has a Large Effect on Plasma Low-Density Lipoprotein Cholesterol in Circumpolar Inuit Populations
Abstract
BACKGROUND: Inuit are considered to be vulnerable to cardiovascular disease because their lifestyles are becoming more Westernized. During sequence analysis of Inuit individuals at extremes of lipid traits, we identified 2 nonsynonymous variants in low-density lipoprotein receptor (LDLR), namely p.G116S and p.R730W.
METHODS AND RESULTS: Genotyping these variants in 3324 Inuit from Alaska, Canada, and Greenland showed they were common, with …
Authors
Dubé JB; Wang J; Cao H; McIntyre AD; Johansen CT; Hopkins SE; Stringer R; Hosseinzadeh S; Kennedy BA; Ban MR
Journal
Circulation Genomic and Precision Medicine, Vol. 8, No. 1, pp. 100–105
Publisher
Wolters Kluwer
Publication Date
2 2015
DOI
10.1161/circgenetics.114.000646
ISSN
1942-325X