Transfusion-Induced Specific Anti–Factor XI Inhibitor in a Patient with Previously Unrecognized Factor XI Deficiency Academic Article uri icon

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abstract

  • This article reports the rare occurrence and investigation of a specific anti-factor XI inhibitor that arose after fresh-frozen plasma infusion into a patient with previously unrecognized Factor XI deficiency. The IgG fraction of the patient's plasma that contained anti-Factor XI antibody was isolated by chromatography on DEAE-Affigel and concentrated. It was shown to exert inhibitory effect on purified Factor XI and XIa both in the activated and nonactivated partial thromboplastin time assay.

authors

  • Musclow, C Elizabeth
  • Amato, Dominick
  • Ofosu, Frederick A
  • Armstrong, A Lynn
  • Abbott, Derrick

publication date

  • March 1, 1988