The Peripheral Nerve Allograft in the Primate Immunosuppressed with Cyclosporin A Academic Article uri icon

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abstract

  • Nerve regeneration across peripheral nerve allografts and control autografts in primates immunosuppressed with Cyclosporin A was quantitatively evaluated by electrophysiologic and histologic methods. Twelve cynomolgus monkeys received 3-cm autografts and allografts in contralateral ulnar nerves. They were immunosuppressed with Cyclosporin A at 25 mg/kg per day or placebo vehicle. Morphometric analysis of nerve graft and distal nerve segments was assessed at 1 year after engraftment. Quantitative electrophysiologic studies were performed percutaneously at 6 and 12 months, and compound action potentials were measured directly across the nerve grafts at 1 year. Excellent regeneration was seen across autografts and allografts in Cyclosporin A-treated and placebo-treated recipients.

authors

  • Bain, James
  • Mackinnon, Susan E
  • Hudson, Alan R
  • Wade, Judy
  • Evans, Peter
  • Makino, Akira
  • Hunter, Daniel

publication date

  • December 1992

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