Journal article
Conflict of Evidence: Resolving Discrepancies When Findings from Randomized Controlled Trials and Meta-analyses Disagree
Abstract
CONTEXT: Clinicians and treatment guideline developers are faced with a dilemma when the results of a new, large, well-conducted randomized controlled trial (RCT) are in direct conflict with the results of a previous systematic review (SR) and meta-analysis (MA).
OBJECTIVE: To explore and discuss possible reasons for disagreement in results from SRs/MAs and RCTs and to provide guidance to clinicians and guideline developers for making …
Authors
Sylvester RJ; Canfield SE; Lam TBL; Marconi L; MacLennan S; Yuan Y; MacLennan G; Norrie J; Omar MI; Bruins HM
Journal
European Urology, Vol. 71, No. 5, pp. 811–819
Publisher
Elsevier
Publication Date
May 2017
DOI
10.1016/j.eururo.2016.11.023
ISSN
0302-2838