Irena Rebalka - McMaster Experts

Affiliations

Faculty of Health Sciences, McMaster University
Member, Michael G. DeGroote Institute for Pain Research and Care (MGD-IPRC), Faculty of Health Sciences
Centre for Metabolism, Obesity, and Diabetes Research (MODR) (Internal), Faculty of Health Sciences
Michael G. DeGroote Institute for Pain Research and Care (MGD-IPRC) (Internal), Faculty of Health Sciences
Assistant Professor, Pathology & Molecular Medicine, Faculty of Health Sciences
Member, Centre for Metabolism, Obesity, and Diabetes Research (MODR), Faculty of Health Sciences

Scholarly Activity in McMaster Experts

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selected scholarly activity

conferences
- Skeletal Muscle Adaptations to Exercise in a Pre‐clinical Model of Myotonic Dystrophy Type 1. The FASEB Journal. 2017
- Myostatin Inhibition as an Adjuvant Therapy in Type 1 Diabetes Mellitus. The FASEB Journal. 2016
journal articles
- Skeletal Muscle Mitochondrial Morphology Negatively Affected in Mice Lacking Xin. Biochemistry and Cell Biology. 102:373-384. 2024
- Isolation of a persistently quiescent muscle satellite cell population. American Journal of Physiology - Cell Physiology. 327:C415-C422. 2024
- The slow-release adiponectin analog ALY688-SR modifies early-stage disease development in the D2.mdx mouse model of Duchenne muscular dystrophy. American Journal of Physiology - Cell Physiology. 326:C1011-C1026. 2024
- Targeting skeletal muscle health with exercise in people with type 1 diabetes: A protocol for HOMET1D, a prospective observational trial with matched controls. PLoS ONE. 19:e0303448-e0303448. 2024
- GDF15 promotes weight loss by enhancing energy expenditure in muscle. Nature. 619:143-150. 2023
- Electrical stimulation-induced muscle contraction does not reduce intramuscular accumulation of Doxorubicin 24 hours following administration. Physiology. 38:5732754. 2023
- Statins activate the NLRP3 inflammasome and inhibit the Hippo pathway to promote myopathy. Physiology. 38. 2023
- The Acute Effect of Multi-Ingredient Antioxidant Supplementation following Ionizing Radiation. Nutrients. 15:207-207. 2023
- The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology. Molecular Metabolism. 64:101555-101555. 2022
- Multi-Ingredient Supplement Supports Mitochondrial Health through Interleukin-15 Signaling in Older Adult Human Dermal Fibroblasts. Cosmetics. 9:47-47. 2022
- Normal to enhanced intrinsic mitochondrial respiration in skeletal muscle of middle- to older-aged women and men with uncomplicated type 1 diabetes. Diabetologia. 64:2517-2533. 2021
- In vitro Validation Assessment of a Fecal Occult Blood Protein Test for Horses. Journal of Equine Veterinary Science. 104:103695-103695. 2021
- Functional and Molecular Characterization of Skeletal Muscle‐Specific CARM1 Knockout Mice. The FASEB Journal. 35. 2021
- The impact of statins on physical activity and exercise capacity: an overview of the evidence, mechanisms, and recommendations. European Journal of Applied Physiology. 120:1205-1225. 2020
- Statin administration activates system xC⁻ in skeletal muscle: a potential mechanism explaining statin-induced muscle pain. American Journal of Physiology - Cell Physiology. 317:C894-C899. 2019
- Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H₂O₂ emission during impaired oxidative phosphorylation. Journal of Cachexia, Sarcopenia and Muscle. 10:643-661. 2019
- Chronic exercise mitigates disease mechanisms and improves muscle function in myotonic dystrophy type 1 mice. Journal of Physiology. 597:1361-1381. 2019
- Loss of the adipokine lipocalin-2 impairs satellite cell activation and skeletal muscle regeneration. American Journal of Physiology - Cell Physiology. 315:C714-C721. 2018
- The Pleckstrin homology like domain family member, TDAG51, is temporally regulated during skeletal muscle regeneration. Biochemical and Biophysical Research Communications. 495:499-505. 2018
- Statin Therapy Negatively Impacts Skeletal Muscle Regeneration and Cutaneous Wound Repair in Type 1 Diabetic Mice. Frontiers in Physiology. 8:1088. 2017
- Decreased Satellite Cell Number and Function in Humans and Mice With Type 1 Diabetes Is the Result of Altered Notch Signaling. Diabetes. 65:3053-3061. 2016
- Myostatin inhibition therapy for insulin-deficient type 1 diabetes. Scientific Reports. 6:32495. 2016
- Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function. Cell Metabolism. 24:118-129. 2016
- Statin Therapy Alters Lipid Storage in Diabetic Skeletal Muscle. Frontiers in Endocrinology. 7:95. 2016
- Inhibition of PAI-1 Via PAI-039 Improves Dermal Wound Closure in Diabetes. Diabetes. 64:2593-2602. 2015
- AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging. Cell Metabolism. 21:883-890. 2015
- Xin‐deficient mice display myopathy, impaired contractility, attenuated muscle repair and altered satellite cell functionality. Acta Physiologica. 214:248-260. 2015
- Skeletal muscle as a therapeutic target for delaying type 1 diabetic complications. WORLD JOURNAL OF DIABETES. 6:1323-1323. 2015
- Potential Biomarkers of Skeletal Muscle Damage. Biomarkers in Medicine. 8:375-378. 2014
- Impaired Macrophage and Satellite Cell Infiltration Occurs in a Muscle-Specific Fashion Following Injury in Diabetic Skeletal Muscle. PLoS ONE. 8:e70971-e70971. 2013
preprints
- Skeletal Muscle Mitochondrial Morphology Negatively Affected by Loss of Xin 2023
- The adiponectin analogue ALY688-SR attenuates diaphragm fibrosis, atrophy and mitochondrial stress in a mouse model of Duchenne muscular dystrophy 2023