Intracerebral haemorrhage in previously healthy adults following aerobic and anaerobic exercise

PRIMARY OBJECTIVE: Intracerebral haemorrhage (ICH) without demonstrated tissue pathology in previously healthy adults has not been previously linked to anaerobic or aerobic exercise. The possible mechanisms and risk factors for ICH that may be found in a young, "healthy" adult are described. RESEARCH DESIGN: Case reports of two patients who suffered a frontal lobe ICH following aerobic and anaerobic exercise are presented. A review of the literature was carried out to elucidate the risk factors for ICH in previously healthy adults. MAIN OUTCOMES: Hypocholesterolemia below 4.14 mmol/l, phenylpropanolamine use above 75 mg per day and certain apolipoprotein phenotypes (Apo E2 and Apo E4), which can all be found in young, healthy adults have all been described in the literature as contributors to the risk of ICH. CONCLUSIONS: There is a need for these risk factors to be researched in more detail, given that potential risk modifiers may help decrease their posed threat.