Evaluation of Approximate Stochastic Hodgkin-Huxley Models

Fox and colleagues [1], [2] derived an algorithm based on stochastic differential equations for approximating the kinetics of ion channel gating that is substantially simpler and faster than “exact” algorithms for simulating Markov process models of channel gating. However, Mino and colleagues [3] argued that the approximation may not be sufficiently accurate in describing the statistics of action potential generation. Bruce [4] subsequently …