Journal article
Immunity Against Heterosubtypic Influenza Virus Induced By Adenovirus And MVA Expressing Nucleoprotein And Matrix Protein-1
Abstract
Alternate prime/boost vaccination regimens employing recombinant replication-deficient adenovirus or MVA, expressing Influenza A virus nucleoprotein and matrix protein 1, induced antigen-specific T cell responses in intradermally (ID) vaccinated mice; with the strongest responses resulting from Ad/MVA immunization. In BALB/C mice the immunodominant response was shifted from the previously identified immunodominant epitope to a novel epitope …
Authors
Lambe T; Carey JB; Li Y; Spencer AJ; van Laarhoven A; Mullarkey CE; Vrdoljak A; Moore AC; Gilbert SC
Journal
Scientific Reports, Vol. 3, No. 1,
Publisher
Springer Nature
Publication Date
2013
DOI
10.1038/srep01443
ISSN
2045-2322
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AdenoviridaeAdministration, IntranasalAnimalsCD8-Positive T-LymphocytesCytokinesFemaleGenetic VectorsImmunization, SecondaryInfluenza VaccinesAlphainfluenzavirusInjections, IntradermalInterferon-gammaMiceMice, Inbred BALB CMice, Inbred C57BLNucleocapsid ProteinsOrthomyxoviridae InfectionsRNA-Binding ProteinsSpleenVaccinia virusViral Core ProteinsViral Matrix Proteins