Journal article
Effects of prenatal immune activation on amphetamine-induced addictive behaviors: Contributions from animal models
Abstract
BACKGROUND: Prenatal environmental adversities may affect brain development and are associated with increased risk for schizophrenia, an illness with 50% comorbidity with addiction. Maternal immune activation by poly-inosinic-citidilic acid (Poly(I:C)) exposure can promote behavioral alterations consistent with schizophrenia symptoms in rodents.
OBJECTIVES: Considering the vulnerability to addiction in patients with schizophrenia, we evaluated …
Authors
Borçoi AR; Patti CL; Zanin KA; Hollais AW; Santos-Baldaia R; Ceccon LMB; Berro LF; Wuo-Silva R; Grapiglia SB; Ribeiro LTC
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 63, , pp. 63–69
Publisher
Elsevier
Publication Date
12 2015
DOI
10.1016/j.pnpbp.2015.05.015
ISSN
0278-5846