Journal article
Transcriptomic and functional analyses of 3D placental extravillous trophoblast spheroids
Abstract
Placental extravillous trophoblast (EVT) invasion is essential in establishing proper blood supply to the fetus during pregnancy. However, traditional 2D in vitro systems do not model the in vivo invasion process in an anatomically-relevant manner. Our objectives were to develop a 3D spheroid model that would allow better emulation of placental invasion in vitro and to characterize the transcriptomic and functional outcomes. HTR8/SVneo EVT …
Authors
Wong MK; Wahed M; Shawky SA; Dvorkin-Gheva A; Raha S
Journal
Scientific Reports, Vol. 9, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41598-019-48816-8
ISSN
2045-2322