Bucindolol for the Maintenance of Sinus Rhythm in a Genotype-Defined HF Population The GENETIC-AF Trial

Abstract

OBJECTIVES: The purpose of this study was to compare the effectiveness of bucindolol with that of metoprolol succinate for the maintenance of sinus rhythm in a genetically defined heart failure (HF) population with atrial fibrillation (AF). BACKGROUND: Bucindolol is a beta-blocker whose unique pharmacologic properties provide greater benefit in HF patients with reduced ejection fraction (HFrEF) who have the beta₁-adrenergic receptor (ADRB1) …

Authors

Piccini JP; Abraham WT; Dufton C; Carroll IA; Healey JS; van Veldhuisen DJ; Sauer WH; Anand IS; White M; Wilton SB

Journal

JACC Heart Failure, Vol. 7, No. 7, pp. 586–598

Publisher

Elsevier

Publication Date

July 2019

DOI

10.1016/j.jchf.2019.04.004

ISSN

2213-1779

Associated Experts

Jeffrey Sean Healey

Professor, Faculty of Health Sciences

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