Journal article
Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis
Abstract
Commensal bacteria influence host physiology, without invading host tissues. We show that proteins from segmented filamentous bacteria (SFB) are transferred into intestinal epithelial cells (IECs) through adhesion-directed endocytosis that is distinct from the clathrin-dependent endocytosis of invasive pathogens. This process transfers microbial cell wall-associated proteins, including an antigen that stimulates mucosal T helper 17 (TH17) cell …
Authors
Ladinsky MS; Araujo LP; Zhang X; Veltri J; Galan-Diez M; Soualhi S; Lee C; Irie K; Pinker EY; Narushima S
Journal
Science, Vol. 363, No. 6431,
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
March 8, 2019
DOI
10.1126/science.aat4042
ISSN
0036-8075