Journal article
Soluble Epoxide Hydrolase-Derived Linoleic Acid Oxylipins in Serum Are Associated with Periventricular White Matter Hyperintensities and Vascular Cognitive Impairment
Abstract
White matter hyperintensities (WMH) are presumed to indicate subcortical ischemic vascular disease but their underlying pathobiology remains incompletely understood. The soluble epoxide hydrolase (sEH) enzyme converts anti-inflammatory and vasoactive cytochrome p450-derived polyunsaturated fatty acid epoxides into their less active corresponding diol species. Under the hypothesis that the activity of sEH might be associated with subcortical …
Authors
Yu D; Hennebelle M; Sahlas DJ; Ramirez J; Gao F; Masellis M; Cogo-Moreira H; Swartz RH; Herrmann N; Chan PC
Journal
Translational Stroke Research, Vol. 10, No. 5, pp. 522–533
Publisher
Springer Nature
Publication Date
October 2019
DOI
10.1007/s12975-018-0672-5
ISSN
1868-4483