Journal article
A Mendelian Randomization-Based Approach to Identify Early and Sensitive Diagnostic Biomarkers of Disease
Abstract
BACKGROUND: Identifying markers of chronic kidney disease (CKD) that occur early in the disease process and are specific to loss of kidney function rather than other underlying causes of disease may allow earlier, more accurate identification of patients who will develop CKD. We therefore sought to identify diagnostic blood markers of early CKD that are caused by loss of kidney function by using an innovative "reverse Mendelian randomization" …
Authors
Mohammadi-Shemirani P; Sjaarda J; Gerstein HC; Treleaven DJ; Walsh M; Mann JF; McQueen MJ; Hess S; Paré G
Journal
Clinical Chemistry, Vol. 65, No. 3, pp. 427–436
Publisher
Oxford University Press (OUP)
Publication Date
March 1, 2019
DOI
10.1373/clinchem.2018.291104
ISSN
0009-9147