Journal article
Preservatives in the vehicle of naloxone: pharmacological effects
Abstract
The pharmacological activity of the preservatives methyl and propyl hydroxybenzoate, until recently components of the vehicle of naloxone (Narcan), was investigated in vitro. This vehicle produced reversible, concentration-dependent relaxation of guinea pig trachea, not mediated via adrenergic or cholinergic receptors, prostanoid activity or phosphodiesterase inhibition. Sensitivity of the tissue to calcium-induced contraction was decreased. In …
Authors
Soulioti AMA; Woods NM; Cobbold PH; Rodger IW
Journal
Biomedicine & Pharmacotherapy, Vol. 43, No. 10, pp. 771–777
Publisher
Elsevier
Publication Date
1989
DOI
10.1016/0753-3322(89)90166-2
ISSN
0753-3322