Sr2+ may differentiate high and low affinity Ca2+...

Sr2+ may differentiate high and low affinity Ca2+ stores in guinea-pig trachealis

Abstract

1. In guinea-pig trachealis Ca2+ are mobilized from different stores to produce the contractions to various agents. 2. Sr2+ can substitute for Ca2+ and maintain responses to KC1 but not responses to A23187 or agents acting via drug-receptor interaction. 3. Resting tone and responses to KC1 are supported by low affinity Ca2+. 4. Responses to the other agents are supported by high affinity Ca2+.

Authors

Raeburn D; Rodger IW

Journal

Vascular Pharmacology, Vol. 18, No. 6, pp. 605–608

Publisher

Elsevier

Publication Date

January 1, 1987

DOI

10.1016/0306-3623(87)90031-0

ISSN

1537-1891

Associated Experts

Ian Rodger

Professor Emeritus, FHSMED

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