Journal article
Effects of leukotriene D4 on the mechanical and electrical properties of guinea‐pig isolated trachealis
Abstract
1. The effects of leukotriene D4 (LTD4) on mechanical and electrical activity were examined in guinea-pig isolated trachealis muscle and compared with two other bronchoconstrictors, methacholine and potassium chloride (KCl). 2. LTD4 elicited concentration-dependent increases in tension in trachealis muscle which were slower in time course than responses induced by either methacholine or KCl. The maximum response to LTD4 was approximately 85% of …
Authors
McCaig DJ; Rodger IW
Journal
British Journal of Pharmacology, Vol. 94, No. 3, pp. 729–736
Publisher
Wiley
Publication Date
July 1988
DOI
10.1111/j.1476-5381.1988.tb11582.x
ISSN
0007-1188