Journal article
Genetic Tools for Coronary Risk Assessment in Type 2 Diabetes: A Cohort Study From the ACCORD Clinical Trial
Abstract
OBJECTIVE: We evaluated whether the increasing number of genetic loci for coronary artery disease (CAD) identified in the general population could be used to predict the risk of major CAD events (MCE) among participants with type 2 diabetes at high cardiovascular risk.
RESEARCH DESIGN AND METHODS: A weighted genetic risk score (GRS) derived from 204 variants representative of all the 160 CAD loci identified in the general population as of …
Authors
Morieri ML; Gao H; Pigeyre M; Shah HS; Sjaarda J; Mendonca C; Hastings T; Buranasupkajorn P; Motsinger-Reif AA; Rotroff DM
Journal
Diabetes Care, Vol. 41, No. 11,
Publisher
American Diabetes Association
Publication Date
November 1, 2018
DOI
10.2337/dc18-0709
ISSN
0149-5992
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedCohort StudiesCoronary Artery DiseaseDiabetes Mellitus, Type 2Diabetic AngiopathiesFemaleFenofibrateGenetic Association StudiesGenetic MarkersGenetic Predisposition to DiseaseHumansMaleMiddle AgedMolecular Diagnostic TechniquesPolymorphism, Single NucleotideRisk AssessmentRisk FactorsSimvastatin