Journal article
Extracellular matrix surface regulates self-assembly of three-dimensional placental trophoblast spheroids
Abstract
The incorporation of the extracellular matrix (ECM) is essential for generating in vitro models that truly represent the microarchitecture found in human tissues. However, the cell-cell and cell-ECM interactions in vitro remains poorly understood in placental trophoblast biology. We investigated the effects of varying the surface properties (surface thickness and stiffness) of two ECMs, collagen I and Matrigel, on placental trophoblast cell …
Authors
Wong MK; Shawky SA; Aryasomayajula A; Green MA; Ewart T; Selvaganapathy PR; Raha S
Journal
PLOS ONE, Vol. 13, No. 6,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0199632
ISSN
1932-6203