Journal article
Subtype- and response element-dependent differences in transactivation by peroxisome proliferator-activated receptors α and γ
Abstract
Peroxisome proliferator-activated receptors (PPAR) modulate transcription by binding to specific peroxisome proliferator-response elements (PPRE) through heterodimerization with the 9-cis retinoic acid receptor (RXR). To investigate potential subtype- and response element-dependent differences in transcriptional activation by PPARs, we expressed PPARalpha or PPARgamma2, along with RXRalpha, in the yeast Saccharoromyces cerevisiae and compared …
Authors
Kassam A; Hunter J; Rachubinski RA; Capone JP
Journal
Molecular and Cellular Endocrinology, Vol. 141, No. 1-2, pp. 153–162
Publisher
Elsevier
Publication Date
June 1998
DOI
10.1016/s0303-7207(98)00085-9
ISSN
0303-7207
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Acyl-CoA OxidaseAnimalsBinding, CompetitiveCell LineDNA-Binding ProteinsDimerizationElectrophoresis, Polyacrylamide GelGene DosageGenes, ReporterMiceOligonucleotidesOxidoreductasesPeroxisome ProliferatorsPromoter Regions, GeneticRatsReceptors, Cytoplasmic and NuclearReceptors, Retinoic AcidRecombinant ProteinsResponse ElementsRetinoid X ReceptorsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsTranscriptional ActivationTransfection