Journal article
Effects of spironolactone and RU486 on gene expression and cell proliferation after freshwater transfer in the euryhaline killifish
Abstract
We have explored the possible mechanisms by which mineralocorticoid (MR) and glucocorticoid (GR) receptors regulate the response to freshwater transfer in the gills of the euryhaline killifish Fundulus heteroclitus. Killifish were implanted with RU486 (GR antagonist) or spironolactone (MR antagonist) at doses of 0.1–1.0 mg g−1, and subsequently transferred from 10‰ brackish water to freshwater. Compared to brackish water sham fish, mRNA …
Authors
Scott GR; Keir KR; Schulte PM
Journal
Journal of Comparative Physiology B, Vol. 175, No. 7, pp. 499–510
Publisher
Springer Nature
Publication Date
October 2005
DOI
10.1007/s00360-005-0014-2
ISSN
0174-1578
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adaptation, PhysiologicalAnimalsCell ProliferationCystic Fibrosis Transmembrane Conductance RegulatorFresh WaterFundulidaeGene ExpressionGillsIon TransportMifepristoneMineralocorticoid Receptor AntagonistsRNA, MessengerReceptors, GlucocorticoidReceptors, MineralocorticoidSeawaterSodium-Potassium-Chloride SymportersSodium-Potassium-Exchanging ATPaseSolute Carrier Family 12, Member 2Spironolactone