Role of knee kinematics and kinetics on performance and disability in people with medial compartment knee osteoarthritis

BACKGROUND: Although gait characteristics have been well documented in people with knee osteoarthritis, little is known about the relationships between gait characteristics and performance or disability. Our purpose was to examine the role of knee kinematics and kinetics on walking performance and disability in people with knee osteoarthritis. We also examined whether pain mediated the relationship between the knee adduction moment and performance or disability. METHODS: Three-dimensional gait analysis was conducted on 54 people with medial compartment knee osteoarthritis. Performance was quantified with the Six Minute Walk test and disability was self-reported on the Short Form-36. The pain subscale of the Western Ontario McMaster Universities Osteoarthritis Index and the functional self-efficacy subscale of the Arthritis Self-Efficacy scale were completed. FINDINGS: A step-wise linear regression demonstrated that the variance in Six Minute Walk test scores was explained by functional self-efficacy (50%) and the range of knee motion (8%). The variance in Short Form-36 was explained by pain (36%), the peak extension angle (19%) and the range of knee motion (4%). Pain was unrelated to the knee adduction moment so analyses of pain as a mediator of the adduction moment on either performance or disability were halted. INTERPRETATION: Kinematic output from the motor control system is useful in understanding some variance in current performance and disability in people with knee osteoarthritis. The knee adduction moment was unrelated to these variables and pain did not mediate between the knee adduction moment and performance or disability. Therefore this moment does not explain current clinical status in people with knee osteoarthritis based on the measures of performance and disability used in this study.