Journal article
CXCL12/CXCR4 Signaling Enhances Human PSC-Derived Hematopoietic Progenitor Function and Overcomes Early In Vivo Transplantation Failure
Abstract
Human pluripotent stem cells (hPSCs) generate hematopoietic progenitor cells (HPCs) but fail to engraft xenograft models used to detect adult/somatic hematopoietic stem cells (HSCs) from donors. Recent progress to derive hPSC-derived HSCs has relied on cell-autonomous forced expression of transcription factors; however, the relationship of bone marrow to transplanted cells remains unknown. Here, we quantified a failure of hPSC-HPCs to survive …
Authors
Reid JC; Tanasijevic B; Golubeva D; Boyd AL; Porras DP; Collins TJ; Bhatia M
Journal
Stem Cell Reports, Vol. 10, No. 5, pp. 1625–1641
Publisher
Elsevier
Publication Date
May 2018
DOI
10.1016/j.stemcr.2018.04.003
ISSN
2213-6711