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A Randomized, Double-Blind, Placebo-Controlled,...

Journal article

A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation*

Abstract

OBJECTIVES: To determine the safety and efficacy of recombinant thrombomodulin (ART-123) in patients with suspected sepsis-associated disseminated intravascular coagulation. DESIGN: Phase 2b, international, multicenter, double-blind, randomized, placebo-controlled, parallel group, screening trial.

Authors

Vincent J-L; Ramesh MK; Ernest D; LaRosa SP; Pachl J; Aikawa N; Hoste E; Levy H; Hirman J; Levi M

Journal

Critical Care Medicine, Vol. 41, No. 9, pp. 2069–2079

Publisher

Wolters Kluwer

Publication Date

September 2013

DOI

10.1097/ccm.0b013e31828e9b03

ISSN

0090-3493

Associated Experts

Mark Crowther

Professor, Faculty of Health Sciences

Labels

Fields of Research (FoR)

32 Biomedical and Clinical Sciences 3202 Clinical sciences 4205 Nursing

Medical Subject Headings (MeSH)

Adolescent Adult Aged Aged, 80 and over Disseminated Intravascular Coagulation Double-Blind Method Female Humans Intensive Care Units Male Middle Aged Outcome Assessment, Health Care Placebos Recombinant Proteins Sepsis Thrombomodulin Young Adult

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