Journal article
Functional Modifications of the Coupling of Solubilized Dopamine D2 Receptors to Guanine-Nucleotide-Binding Proteins
Abstract
The molecular basis for the regulation of high-affinity agonist, [3H]N-n-propylnorapomorphine ([3H]NPA), binding to cholate-solubilized dopamine D2 receptors was characterized using cations, guanine nucleotides and sulfhydryl-modifying agents. [3H]NPA binding displayed an absolute requirement for divalent cations in the solubilized preparation. Removal of Na+ from the solubilized preparation caused an apparent reconstitution of soluble …
Authors
Kazmi SMI; Srivastava LK; Mishra RK
Journal
Neurosignals, Vol. 1, No. 4, pp. 194–207
Publisher
Karger Publishers
Publication Date
1992
DOI
10.1159/000109325
ISSN
1424-862X