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Sulfated cholecystokinin octapeptide (CCK8) failed...
Journal article

Sulfated cholecystokinin octapeptide (CCK8) failed to modulate basal or dopamine-stimulated adenylate cyclase activity in the rat striatum

Abstract

1. In view of previously demonstrated modulatory effects of CCK8 on DA-sensitive adenylate cyclase activity in the nucleus accumbens, we examined the effects of this neuropeptide in the striatum. 2. Adenylate cyclase activity was measured by conversion of alpha-[32P]ATP into [32P]cAMP. 3. CCK8, when added to the adenylate cyclase assay in concentrations up to 100 microM, failed to significantly alter, either positively or negatively, basal or …

Authors

Morency MA; Ross GM; Kajiura JS; Mishra RK

Journal

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 12, No. 2-3, pp. 331–336

Publisher

Elsevier

Publication Date

January 1988

DOI

10.1016/0278-5846(88)90052-8

ISSN

0278-5846