Journal article
A Randomized Phase II Study of Two Schedules of Bryostatin-1 (NSC339555) in Patients with Advanced Malignant Melanoma – A National Cancer Institute of Canada Clinical Trials Group Study
Abstract
Purpose: This study addressed theefficacy and toxicity of the novel compoundBryostatin-1 (NSC 339555), a novel agentwith antineoplastic, hematopoietic andimmunomodulatory activity in a variety ofin vitro and in vivo systems.Patients and methods: This phase IIstudy randomly assignedchemotherapy-naïve patients withuntreated metastatic melanoma andmeasurable disease to two schedules oftreatment: Arm A, 25 μg/m2bryostatin-1 given as a 24 hour …
Authors
Tozer RG; Burdette-Radoux S; Berlanger K; Davis ML; Lohmann RC; Rusthoven JR; Wainman N; Zee B; Seymour L
Journal
Investigational New Drugs, Vol. 20, No. 4, pp. 407–412
Publisher
Springer Nature
Publication Date
November 2002
DOI
10.1023/a:1020694425356
ISSN
0167-6997