Reactivity and selectivity of F2 toward 3,4,6-Tri-O-acetyl-D-Glucal in anhydrous HF: Synthesis of [18F]2-fluoro-2-deoxy-β- D-allose and its use for the detection of a breast tumor

Because of growing interest in the biological properties of D-allose, its 18F-labeled analogue, [18F]2-fluoro-2-deoxy-β-D- allose ([18F]2-FDβA), was synthesized to probe its biological activity. A fast and efficient two-step, regio-, and stereoselective synthesis of [18F]2-FDβA was achieved by electrophilic fluorination of 3,4,6-tri-O-acetyl-D-glucal in anhydrous HF using [18F]F2 and [18F]CH3COOF. The fluorocarbohydrate was characterized by …